Testosterone is “safe” for most older men with low testosterone Health Admin, June 16, 2023 June 16, 2023 — Testosterone replacement therapy does not appear to increase the risk of heart attack, stroke, or death in middle-aged and older men with low testosterone and a higher risk of heart disease, long-awaited results from a large clinical trial have found. . Among more than 5,000 men between the ages of 45 and 80, no increased risk of cardiovascular disease, non-fatal heart attack or stroke was observed. There was also no increased risk of prostate cancer during the 33-month follow-up period. However, there were increases in one type of arrhythmia, atrial fibrillation, acute kidney injury, and blood clots in the lung (pulmonary embolism) in the group that received testosterone replacement therapy compared with those who used a placebo gel. The Food and Drug Administration commissioned the study in 2015 in response to concerns and conflicting data regarding the safety of testosterone replacement therapy in men. It was made by a group of five testosterone replacement product manufacturers, led by AbbVie. The results were to be presented Saturday at ENDO 2023: The Endocrine Society Annual Meeting. The data was also published in New England Journal of Medicine. These results are the first to be reported from the study, called TRAVERSE. Later this year, other findings on so-called “efficacy” findings, including sexual function, depressive disorder, fractures, anemia, and diabetes, are expected to be presented at a conference, and/or published in a medical journal. Taken together, the results of TRAVERSE are expected to transform risk-benefit discussions with patients about the use of testosterone therapy for low testosterone, said study co-author Shalindar Bhasin, MD. See also The US Food and Drug Administration commissioner talks about artificial intelligence and misinformation“Testosterone deficiency does not kill people as far as we know but it is in fact an important symptomatic condition that affects quality of life. Many middle-aged and older men seek help for these symptoms, so it is an important condition and treatment decisions are complex,” said Bhasin, program director. Research in men’s health: aging and metabolism at Brigham and Women’s Hospital, Boston. . “We will have much better data on efficacy in the next few months,” he added. Real data on something we’ve been sorting for decades. Asked for comment, endocrinologist Bradley D. The “community of doctors prescribing testosterone to men has been anxiously awaiting” the TRAVERSE results. So far, we’ve had to say well, there could be a risk of strokes and heart attacks. said Anwalt, a professor of medicine at the University of Washington in Seattle However, Anawalt stressed that the safety data for TRAVERSE only applies to men with documented low testosterone. “It doesn’t give carte blanche to prescribe men with normal testosterone concentrations. It doesn’t tell us about the safety of it,” he said. In closing, let us remember that every ending brings forth a new beginning. As we conclude this article, may we embrace the lessons learned, the insights gained, and the possibilities that lie ahead. Together, let us step forward with courage and optimism, for the journey continues , and our potential knows no bounds. Source_by_webmd.com/ Health MenoldersafeTestosterone